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Applying Procedures For Stem Cells Transplant


Tzu Chi Stem Cells center is established solely for the purpose on benefiting all patients with blood diseases and is operating through assembling the donation, kindness and efforts of generous people far and wide. In order to let more people understanding the application of matching bone marrow for the unrelated transplantation, we will introduce the procedure phase by phase for a registry or a transplant center to request a match thru transplant for the patient.

1. Preliminary Matching
Aim: To assist the applicant gaining the initial understanding of the quantity of potential matching donors from our center with the patient.
Application Requirements: Anyone can file a preliminary matching request.
Application Documents: Examination report of the patients HLA examination, which must contain A, B and DR three locus, regardless of resolution.
Application Methods: Please put down the applicants name and contact information, and sent the above-mentioned examination reports through e-mail or fax to Tzu Chi Stem Cells center.


2. Formal Matching
Aim: To provide the patients doctor with unrelated donors HLA typing and its matching result for further matching process.
Application Requirements: Application either from the registry or the doctor of the transplant center once the patient and his doctor confirmed to proceed the unrelated stem cells transplantation.
Application Documents: Patients Preliminary Search Request form, letter of authorization for research and related documents.
Application Methods: Please fax all above-mentioned documents to our center. (Please see Note)
Points of Attention: The standards of the center on providing stem cells are as below.
Stem cells donors HLA low resolution must reach 5/6 matched with the patients.
HLA low resolution of umbilical cord blood matching must reach 4/6.
(Note: For Taiwan based transplanting hospitals, the doctor is obliged to provide the patients information, including identity number, blood type, weight and the patients family contact number and address upon filling the preliminary matching application document. This allows the center to arrange volunteer caring unit to visit and attend to the patient. If the patients family prefers not to have this arrangement, please notify it clearly upon submitting the application form.)


3. Initiating Donors Matching Process
Aim: Contact the donor and ensure donors willingness on donation. Extracting second blood sample has to be done after the health screening for the Confirmatory Test (CT) and test of Infectious Disease Markers (IDMs).
Application Requirements: The registry or the doctor of the transplant center can initiate the matching process.
Application Documents: Sample Shipment Request Form, which states the donors ID, locus of examination and designated HLA examination laboratory.
Application Methods: Please e-mail or fax all the documents to our center.
Points of Attention:
The CT of the donor processed by BTCSCC is a High Resolution examination of HLA-A, B, DRB1 three locus, plus the test of IDMs.
A Sample Shipment Request Form must be filled out if the donors blood sample is to be sent to the designated HLA laboratory, and the testing result must be returned to BTCSCC by the transplant center.
The validity of IDMs is 30 days.
Taiwan patient: The fee for the first 5 matching donors chosen by the contracted transplant centers to do CT (A, B, DR) or DR is covered by Tzu Chi Stem Cells center. Patient has to pay for the exams of Cw or DQB1 or other loci according to the centers fee schedule. If more than 5 matching donors are chosen, each extra donors examination expense will need to be paid by the patient according to our centers fee schedule.


4. Donors Health Check-Up Procedure
Aim: After receiving donors CT and infectious disease makers (IDMs) report, if the doctor decided to choose this donor for SC donation, then the donor must be arranged for a health check-up in order to ensure the donor is in a good condition.
Application Documents: Patient Status Report and Donor Work-up Request Form.
Application Methods: Patients doctor is asked to prepare and fill in all the forms and send to our center by e-mail or fax upon completion.
Points of Attention:
The Medical Director of BTCSCC will have the right of final approval on whether or not the donor is suitable for donation.
Regardless to donors health check-up results on the suitability of SC donation, all the expenses generated from the health check-up must be paid by the patient.
When a female donor undergoes health check-up, a blood serum pregnancy test will also be done. The earliest possible date of donation will be drawn up and reply to TC immediately if the donor is pregnant.
The health check-up report issued by Tzu Chi Stem Cells center is valid for 6 months.


5. Procedure of collecting donors stem cells
Aim: Collecting donors stem cells for transplant to the patient.
Application Documents:
Donor Final Clearance Report
Prescription form for bone marrow or mobilized stem cells product
Application Methods: After receiving the health check-up report of the donor from BTCSCC, the registry or the transplant center can initiate the donation procedure for the qualified stem cells donors. The registry or the transplant centers doctor must complete the above-mentioned 2 documents, and sent to our center by e-mail or fax.
Tzu Chi Stem Cells Centers Collection Standards:
Bone Marrow: The body weight is based on the lighter of weight of the donor or the bone marrow recipient. If the patients body weight is less than 30 kg, 30kg will be used as criterion. Standard total Nucleated Cells counts is based on the body weight(kg) x 20 x 0.22.
PBSC: Recipients body weight (kg) x 5 x 10^6 is the standard for requesting PBSC CD34 + cells count.
Picking up marrow: Please provide the itinerary of the courier after picking up date and the transplanting date have been confirmed, so we can arrange the collecting schedule. Search Unit staff will prepare all clearance documents for the courier to pick up the marrow.
Points of Attention:
The maximum pre-collection blood sample is limited to 100ml. Should the transplant center need special blood samples during the collection of HSC, such as plasma, please make a special note on the Prescription form.
Total blood samples at time of collection are limited to a maximum of 20ml.


Applying Procedures For Stem Cells Transplant(E6A0021B01) pdf 251KB
Download file:  
1. Application for participation as a transplant center(E6A0022A24-01) pdf 153KB
2. Preliminary Search Request Form(E6A0021666-05) pdf 112KB
3. Sample Shipment Request Form(E6A0021857-02) pdf 191KB
4. Donor Work-up Request Form(E6A0021674-04) pdf 66KB
5. Donor Final Clearance Report(E6A0021863-05) pdf 50KB
6. Prescription form for bone marrow or mobilized stem cells product
pdf 45KB
7. Subsequent Donation Request Form(BAK0001) pdf 45KB
8. Patient Status Report and Prescription for Cord Blood Unit
pdf 124KB

Should you have any questions, please contact Tzu Chi Stem Cells Center.
Tel: 886-3-8561825 Ext: 3518/3519/3216 Fax: 886-3-8574324
707 Sec. 3, Chung Yang Rd., Hualien, Taiwan 970, R.O.C.

Update: Feb. 2010

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